Devil's Claw Gel 98% Extra Strong, 100 ml, Made in Italy for Massage to Joints and Muscles, Natural Formula and Dermatologically Tested on Sensitive Skin - Dulàc Pharma

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More high-quality studies are needed, but current research suggests that devil’s claw may be effective at reducing pain associated with osteoarthritis. Chantre P, Cappelaere A, Leblan D, et al. Efficacy and tolerance or Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000;7:177-83. View abstract. Kikuchi T. New iridoid glucosides from Harpagophytum procumbens. Chem Pharm Bull 1983;31:2296-2301.

Brien, S., Lewith, G. T., and McGregor, G. Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety. J Altern Complement Med 2006;12:981-993. View abstract. Versus Arthritis, the UK’s leading arthritis research charity, says ‘evidence suggests that devil’s claw may be as effective as conventional medicines for osteoarthritis. 10 Common medications may also negatively interact with devil’s claw, including prescription nonsteroidal anti-inflammatory drugs (NSAIDs), blood thinners and stomach acid reducers ( 31): Stomach acid reducers: Devil’s claw may decrease the effects of stomach acid reducers, such as Pepcid, Prilosec and Prevacid. Though devil’s claw has not been studied extensively in humans, preliminary evidence suggests that it may be an alternative treatment for inflammatory conditions. Summary

Is it safe?

Cuspidi C, Sala C, Tadic M, et al. Systemic hypertension induced by Harpagophytum procumbens (devil's claw): a case report. J Clin Hypertens (Greenwich) 2015;17:908-10. View abstract.

This is not an all-inclusive list of medication interactions. To be on the safe side, always discuss your use of supplements with your doctor. Summary Inflammation is your body’s natural response to injury and infection. When you cut your finger, bang your knee or come down with the flu, your body responds by activating your immune system ( 6). For example, a study in mice showed that harpagoside significantly suppressed the action of cytokines, which are molecules in your body known to promote inflammation ( 14).The root of the Devil Claw herb tends to be dried out, powdered, and used in remedies. One of this root’s most potent active ingredients is Iridoid Glycosides - a group of compounds thought to be responsible for its beneficial effects. Generally, their quality of life improved and 60% of patients either reduced or stopped some of their pain medication. Chrubasik S, Sporer F, and Wink M. [Content of active substance in tea preparations from Harpagophytum procumbens]. Forsch Komplementarmed 1996;3:116-119. Diabetes: Devil’s claw may reduce blood sugar levels and intensify the effects of diabetes medications.

Devil’s claw has been proposed as a potential remedy for inflammatory conditions because it contains plant compounds called iridoid glycosides, particularly harpagoside. In test-tube and animal studies, harpagoside has curbed inflammatory responses ( 13).Devil’s claw appears to be safe when taken in doses up to 2,610 mg daily, though long-term effects have not been investigated ( 29). For example, one clinical study involving 122 people with osteoarthritis of the knee and hip suggested that 2,610 mg of devil’s claw daily may be as effective at reducing osteoarthritis pain as diacerein, a medication commonly used to treat this condition ( 17). Teut, M. and Warning, A. [Bone metastases in breast carcinoma]. Forsch Komplement.Med 2006;13:46-48. View abstract. Kundu, J. K., Mossanda, K. S., Na, H. K., and Surh, Y. J. Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets. Cancer Lett. 1-31-2005;218:21-31. View abstract.

If there is no relief after three to five days, you can increase the dose to two tablets twice a day. One of this root’s most potent active ingredients is iridoid glycosides - a group of compounds thought to be responsible for its beneficial effects. What is devil’s claw used for? Lanhers MC, Fleurentin J, Mortier F, et al. Anti-inflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens. Planta Med 1992;58:117-23 . View abstract. Some but not all studies suggest that iridoid glycosides may also have antioxidant effects. This means the plant may have the ability to ward off cell-damaging effects of unstable molecules called free radicals ( 3, 4, 5).

Devil’s claw root

Erdos, A., Fontaine, R., Friehe, H., Durand, R., and Poppinghaus, T. [Contribution to the pharmacology and toxicology of different extracts as well as the harpagosid from Harpagophytum procumbens DC]. Planta Med 1978;34:97-108. View abstract.